How to reverse age? Is it possible to reverse age in humans? (2023)

Since the birth of an organism, it keeps growing. Ageing is a natural process that occurs in all living organisms, and it is caused by various factors, including cellular damage, genetic factors, environmental factors, and lifestyle factors. While there are various treatments and lifestyle changes that can slow down the ageing process and help people maintain a more youthful appearance and function, there is currently no known way to reverse the ageing process completely.

There have been many claims about anti-ageing therapies, including dietary supplements, hormone therapies, and stem cell therapies. However, the efficacy and safety of these therapies are still uncertain, and most of them have not been rigorously tested in humans.

It is important to note that ageing is a complex process that affects every part of the body, and any attempts to reverse it must be carefully evaluated and tested to ensure that they are safe and effective. At present, the best ways to slow down the ageing process and maintain good health are to follow a healthy lifestyle, including regular exercise, a balanced diet, stress management, and avoiding harmful habits like smoking and excessive alcohol consumption.

What is Reverse ageing?

Reverse ageing, also referred to as age reversal, is a process that aims to slow down, halt, or even reverse the ageing process in living organisms. The idea behind reverse ageing is that ageing is not necessarily an inevitable process and can be prevented or reversed through various interventions.

The process or techniques that an individual adopts to reverse their age biologically is the core base of longevity. A healthy diet, regular exercise, biohacking along with the intake of longevity supplements, are prime measures that can dramatically aid in one’s reverse ageing process. Of course, if someone is 40 years old right now, they cannot be 30! When one talks about age reversal, it is reducing the ill effects of ageing rather than actually reversing the ageing process.

(Video) Scientists Are Learning How to Reverse Aging

What is the science behind the Reverse ageing process?

The process of ageing is a complex and multifactorial phenomenon that is influenced by a wide range of biological, environmental and lifestyle factors. Although the ageing process is inevitable there are strategies that can be employed to slow down or even reverse some of the signs of ageing.

At the cellular level, ageing is associated with a decline in the function and efficiency of various biological processes. One of the key mechanisms involved in the ageing process is oxidative stress, which results from an imbalance between the production of reactive oxygen species (ROS) and the body's antioxidant defences. ROS can damage cellular components such as DNA, proteins, and lipids, leading to cellular dysfunction and death. There are around 14 hallmarks of ageing that have been described that cause ageing. Targeting each one of these hallmarks is the key and science of reversing ageing.

Several approaches have been proposed to reverse the ageing process, including:

  1. Caloric restriction: Reducing the number of calories consumed has been shown to extend lifespan and delay the onset of age-related diseases in many animal models.
  2. Exercise: Regular physical activity has been linked to improved health and longevity, likely due to its ability to reduce oxidative stress and inflammation and improve cellular function.
  3. Antioxidants: Consuming foods and supplements that are high in antioxidants can help to reduce oxidative stress and protect against age-related damage.
  4. Hormone replacement therapy: Replacing declining hormone levels, such as testosterone or estrogen, can help to slow down or reverse some of the effects of ageing.
  5. Stem cell therapy: The use of stem cells to regenerate and repair damaged tissues and organs has shown promise in reversing some age-related conditions.
  6. Intake of longevity supplements: The safest, most affordable and easiest option out there to combat ageing and its ill processes.

Reverse Ageing Supplements to consume

Nicotinamide adenine dinucleotide (NAD+)

Nicotinamide adenine dinucleotide is a coenzyme that plays a crucial role in over 500 enzymatic reactions in the body by facilitating electron transfer between molecules during metabolism. However, NAD+ levels decline with age, increasing the risk of various health issues. While calorie restriction, exercise, and fasting can help maintain or increase NAD+ levels, NMN supplements offer a faster solution as they are a precursor to NAD+ and can quickly convert to it. By increasing NAD+ levels, NMN tablets can slow down or even reverse the ageing process.


Resveratrol is a natural polyphenol found in grape skin and seeds, has gained popularity in ageing and longevity research due to its antioxidant, anticarcinogenic, antitumor, and estrogenic/antiestrogenic properties. This supplement acts as an antioxidant, protecting cells from oxidative damage, and can be challenging to obtain through diet alone. A high-quality supplement can provide optimal levels of Resveratrol for overall health and skincare. Individuals with diabetes, depression, or heart problems can benefit significantly from taking Resveratrol, as it can work together to regulate blood sugar levels, promote cardiovascular health, and improve skin naturally.

(Video) 3 Evidence Based Ways to Reverse Aging 🧬


Spermidine is a naturally occurring polyamine that can activate autophagy and potentially reverse ageing effects. With multiple amine groups, spermidine interacts with DNA, RNA, and proteins, making it vital for biological processes. Spermidine supplements or foods rich in spermidine can improve brain function, mitochondrial strength, cardiovascular health, and hair growth. Spermidine can mimic fasting's benefits by activating autophagy, promoting longevity and overall health, without the need to fast.


Quercetin is a flavonol belonging to the flavonoid group of plant compounds, known for its powerful antioxidant properties. It cannot be synthesised by the human body but is found in numerous fruits, vegetables, and drinks. Its ability to neutralise free radicals makes it a valuable compound in preventing cell membrane damage and cell death.


Fisetin is a flavonoid commonly found in fruits and vegetables such as strawberries, grapes, cucumbers, and onions, has emerged as a promising anti-ageing compound. It has been shown to act as a senotherapeutic, selectively inducing cell death in unhealthy cells and reducing chronic inflammation, which can improve overall cellular health and increase lifespan.


Ca-AKG is a stable form of alpha-ketoglutarate (AKG), a naturally occurring substance found in the body. AKG is produced during cellular energy production and provides vital fuel to support cell growth and protect cells. Additionally, it aids in the healing process of injured muscle tissue, supports digestive health, and enhances kidney function. However, AKG production decreases significantly after the age of 40, leaving the body more vulnerable to age-related illnesses and infirmities.


While ageing is an inevitable process, there are various lifestyle changes and interventions that can help slow down the ageing process and maintain good health. While claims of reversing ageing exist, there is currently no known way to reverse the ageing process completely. Several approaches, including caloric restriction, regular exercise, hormone replacement therapy, stem cell therapy, and intake of longevity supplements like NMN, resveratrol, and spermidine, have shown some promise in reversing some age-related conditions. However, it is essential to be cautious about any claims related to anti-ageing therapies and carefully evaluate their efficacy and safety before use. Ultimately, following a healthy lifestyle, including regular exercise, a balanced diet, stress management, and avoiding harmful habits like smoking and excessive alcohol consumption, is the best way to slow down the ageing process and maintain good health.

(Video) How soon could humans reverse the aging process with genetic engineering?


1. What does it mean to "reverse" age, and is it really possible?

"Reverse ageing" means to reduce the effects of ageing on the body and mind, making a person appear and feel younger. While some age-related changes can be slowed down or managed, reversing the ageing process completely is not yet possible.

2. Can lifestyle factors, such as healthy eating and exercise, help to slow or reverse the ageing process?

Yes, a healthy lifestyle that includes a balanced diet, regular exercise, stress management, and avoiding harmful habits like smoking can help slow down the ageing process, reduce the risk of age-related diseases, and improve overall health and well-being.

3. How can individuals take steps to prevent premature ageing and maintain optimal health as they age?

(Video) Man spends millions to attempt to reverse aging

Individuals can prevent premature ageing by adopting a healthy lifestyle, including a balanced diet, regular exercise, stress management, avoiding harmful habits like smoking, getting enough sleep, and protecting the skin from the sun. Regular check-ups and screenings can also detect and manage age-related health issues.

4. What role does genetics play in the ageing process, and how much control do individuals have over their biological age?

Genetics plays a role in the ageing process, but lifestyle factors have a greater influence on biological age. While individuals cannot change their genes, they can modify their lifestyle to slow down the ageing process and reduce the risk of age-related diseases.

5. What are some common misconceptions about reversing age, and how can they be addressed with scientific evidence?

Some common misconceptions about reversing age include that it is possible to completely reverse ageing, that certain supplements or treatments can reverse ageing, and that only expensive or extreme measures can slow down ageing. These claims are not supported by scientific evidence. While a healthy lifestyle can slow down ageing, complete reversal is not yet possible, and supplements or treatments marketed as "anti-ageing" may not have scientific evidence to support their claims.

(Video) How to Stop (And Even Reverse) Aging


How to reverse age? Is it possible to reverse age in humans? ›

Although the paper posits that such a process could be theoretically halted, which would give humans that nice consolation prize of immortality (or at the very least increased longevity), the study concludes that reversing a human's age is biologically impossible.

How can I reverse my age naturally? ›

Phase Out Destructive Habits
  1. The single best thing you can do for your health and longevity is quit smoking. ...
  2. Drink only in moderation. ...
  3. Get your Zzzz's. ...
  4. Find a doctor who specializes in geriatrics or anti-aging. ...
  5. Cut saturated fat, up omega-3 fats. ...
  6. Consider moderating your total food intake.
Aug 28, 2022

What drug reverses aging? ›

In older adults, low doses of rapamycin, an mTOR inhibitor, seem to set mTOR activity back to its youthful state: on when you need it, off when you don't. “When they get rapamycin, their immune systems, which have already been damaged by old age, start to function better,” Mannick says.

Can I reverse my body age? ›

Biological age can increase when people are under stress, but it can be reversed when the tension eases, according to a study published today in Cell Metabolism. Researchers used DNA methylation clocks to measure and note changes in biological age as it responds to stress in humans and mice.

How can I look 20 years younger naturally? ›

19 Easy Ways to Look Younger, According to Experts
  1. Getty Images. ...
  2. Try a Collagen-Based Face Cream. ...
  3. Use a concealer for dark circles. ...
  4. Keep your eye makeup simple. ...
  5. Curl those lashes. ...
  6. Apply SPF Daily. ...
  7. Take your time removing your makeup.
Nov 4, 2022

What protein reverses aging? ›

The authors of the study report that a reduction in the protein menin in the brain's hypothalamus results in neuroinflammation that may cause characteristics of aging. The study suggests that supplements of menin and the amino acid D-serine may be able one day to reverse aspects of aging in humans.

What is the most powerful anti-aging drug? ›

Rapamycin is potentially the most powerful anti-aging drug ever discovered. However, due to its unlucky history, few know of it. In 1972, scientists discovered rapamycin, a compound initially thought to have antifungal properties, in a soil sample from Easter Island.

What is the new longevity drug? ›

Researchers have found that the drug rilmenidine can extend lifespan and slow aging.

What slows down aging? ›

  • Eat a healthy diet. Always remember that what you put into your body will impact on the appearance of your skin. ...
  • Maintain healthy DNA. Vitamin A is essential to life and to your skin. ...
  • Keep your muscles and bones strong. ...
  • A healthy heart. ...
  • Exercise your brain. ...
  • Look after your skin.

How can I fix my body age? ›

How to Age Well
  1. Eat. Small changes in your eating habits can lower your risk for many of the diseases associated with aging. ...
  2. Move. A body in motion will age better than one on the couch. ...
  3. Think. Aging well means taking care of both the body and the mind. ...
  4. Connect. Strengthen Social Ties. ...
  5. Live Well. Stay Out of the Sun.

How to take 10 years off your age? ›

How to Look 10 Years Younger, Instantly
  1. Use a Hydrating Mask. For tighter, glowing skin, put on a hydrating mask for ten minutes. ...
  2. Choose a Luminous Foundation. ...
  3. Lighten Your Hair a Bit. ...
  4. Wear a Ponytail. ...
  5. Exfoliate (But Don't Overdo It) ...
  6. White Out Your Waterline. ...
  7. Finish Your Look With a Mineral Mist.

Which vitamin makes you look younger? ›

Vitamin A (Retinol) Makes Your Skin Look Simply Amazing.

One of vitamin A's forms, called “retinol,” works supremely well to reduce wrinkles, hyperpigmentation, as well as acne. It's the main ingredient found in almost every anti-aging cream out there, and there's a reason for that.

Does caffeine make you look older? ›

Caffeine can cause your blood vessels to constrict, and as a result, the vessels at the surface of your skin won't deliver as many antioxidants and nutrients to promote collagen production. "The results of drinking too much coffee can cause the skin to wrinkle prematurely, and become more lax with time," says Dr. S.

At what age does your face change most? ›

For most people, the answer to “At what age does your face change the most?” is sometime in their 50s or 60s. This is around the time that the effects of gravity and fat loss become extremely noticeable.

Can collagen reverse aging? ›

Collagen can help to reverse signs of skin aging by boosting elasticity in the skin. Drinking collagen powder can also help repair damaged skin and scarring, which seniors are more prone to than younger individuals.

What protein tightens skin? ›

Collagen and elastin are two essential proteins associated with skin firmness. The production of these two proteins decreases as people age .

Does eating a lot of protein age you? ›

Meat or animal protein increases levels of growth hormone, IGF, and insulin, which are all known to accelerate aging and increase the risk of aging-related disease in the long term (R,R,R,R).

What is the best anti-aging drink? ›

Green tea should be near the top of the list when compiling a list of the healthiest beverages for anti-ageing. According to research, green tea can help prevent wrinkles, sun damage, and expression lines that are signs of ageing.

What is the secret to slow aging? ›

Get enough sleep, protect your skin with sunscreen, eat a balanced diet, exercise, and manage your stress. Those are only some of the many ways you can take care of your body as you go through the natural process of aging. If you take care of yourself, your body will thank you in the long run.

What is the number one treatment to look younger? ›

Botox. This is probably the best-known non-surgical facial procedures to look younger.

Why is metformin anti-aging? ›

Metformin also has anti-inflammatory effects, which may contribute to its ability to slow aging. Since chronic inflammation is one hallmark of aging and age-related diseases, reducing inflammation can improve health and life span. “It takes an old cell or an old organ and fixes a lot of things.

Is rapamycin available to the public? ›

Rapamycin and its analog, everolimus, are FDA approved for human use and have been used safely for decades. In 2006, it was suggested that rapamycin could be used immediately to slow down aging and all age-related diseases in humans [2], becoming an “anti-aging drug today” [3].

What is the anti-aging drug in 2023? ›

By the end of 2023, it's likely that one of these ideas will be shown to work in humans. One strong contender is “senolytics,” a class of treatments that targets aged cells—which biologists call senescent cells—that accumulate in our bodies as we age.

What can I drink to look younger? ›

Great news! Red wine is an anti-aging tonic. It helps you to look younger. Research suggests that red wine has multiple benefits including keeping your heart healthy, reducing blood pressure, glowing skin, etc. Daily one or two glass of red wine may give you amazing anti-aging effects.

Why am I looking old all of a sudden? ›

Exposure to light is a top cause of premature aging: Sun exposure causes many skin problems. Ultraviolet (UV) light and exposure to sunlight age your skin more quickly than it would age naturally. The result is called photoaging, and it's responsible for 90% of visible changes to your skin.

What is the best drink to slow aging? ›

The 6 Best Teas To Slow Aging, Say Dietitians
  • Green tea. Green tea is one of the healthiest teas you can drink, especially when it comes to slowing down the aging process. ...
  • Rooibos tea. ...
  • Oolong tea. ...
  • Matcha tea. ...
  • Hibiscus tea. ...
  • Black tea.
Jul 13, 2022

What is the anti-aging drink in the morning? ›

Vitamin C has anti-aging properties and protects the body from chemical toxins, the result is healthy glowing skin. Take a jar full of water and add lemon, pineapple, kiwi, oranges, and other sources of vitamin C, and your morning detox juice is ready!

What ages your face the most? ›

The sun plays a major role in prematurely aging our skin. Other things that we do also can age our skin more quickly than it naturally would. To help their patients prevent premature skin aging, dermatologists offer their patients the following tips. Protect your skin from the sun every day.

How do I know if I look old? ›

When you are young, the stores of fat, collagen and elastin keep your skin full, smooth and youthful. As you age, these stores break down and skin covering these areas begins to sag and wrinkle. You'll see this commonly around your chin and jaw areas, where the skin hangs, adding years to your appearance.

What makes a woman look younger? ›

Retinol and alpha-hydroxy acids (AHAs) can rejuvenate the skin and eliminate fine lines and wrinkles,” Dr. Patel says. “Hyaluronic acid helps your skin retain moisture, which gives it a smooth, glowing look.” Opt for serums and night creams with retinol and AHAs, and a daily face moisturizer with hyaluronic acid.

At what age do you start slowing down? ›

New study says decline begins in our 50s

By the time you reach your 50s, your strength, balance and endurance are already beginning to wane — much earlier than previously thought, according to a new study.


1. Rewinding the biological clock: How to reverse ageing
(nature video)
2. Scientists Discover a Cure to Reverse Human Aging
(The Infographics Show)
3. Scientists Uncover How to Reverse Aging
4. Scientists say they’re getting close to reversing #aging in humans
(Stay Tuned)
5. Humans Living Forever: How Science Can Reverse Aging & Achieve Immortality | Future Documentary Ep.3
(Java Discover | Free Global Documentaries & Clips)
6. How to reverse ageing by three years through diet and lifestyle with Giulia Criscuolo
(SABC News)


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